The OGDH Antibody from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Mouse, and Rat antigen. The OGDH Antibody has been validated for the following applications: Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms